The grip is the same as an ordinary mouse, just turned sideways into a handshake position which avoids forearm twisting for comfort and good health. Many users, including medical doctors, ergonomists and physical therapists, have said the Evoluent VerticalMouse provides superior comfort and even relieved their wrist pain.
The VM3R2 (Evoluent VerticalMouse 3 Rev 2) is compatible with Windows XP, Vista, Windows 7, and Mac OS X (versions 10.4 and newer), as well as basic functionality on Linux. It uses a USB connection and functions without drivers for basic features like left, right, and middle click, though a driver is required for full customization and programming of all five buttons.